Author

J. Eckardt

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Review Open access Aug 2026

Retrieval-Augmented Large Language Models for Clinically Aligned Adverse Event Coding in Acute Myeloid Leukemia Clinical Trials

Evaluation across three AML clinical trials showed that strict LLT-level string agreement underestimated clinical ap-propriateness, highlighting the importance of combining hierarchical evaluation metrics with clini-cal expert validation for AI-assisted MedDRA coding in hematology trials.

N. Dashti, M. Schneider, J. Eckardt et al. · medRxiv · 0 citations

Open access Sep 2026

Benchmarking ten frontier large language models on 1,477 board style multiple choice questions in hematology

Large Language Models (LLMs) are increasingly used by clinicians and patients for medical queries, yet their accuracy and safety at the specialist level in hematology remain insufficiently characterised. We benchmarked ten frontier proprietary and open-weight LLMs across two generations on 1,477 board-style hematology...

M. Radoynova, M. Benouis, F. Schulze et al. · medRxiv · 0 citations