J. Edwards

A versatile inducible plant model system for dissecting p53 function and discovering novel interaction networks

Summary p53, a key tumor suppressor in animals, prevents DNA damage by arresting the cell cycle, activating repair, or inducing cell death. Mutations in p53 are found in over half of human cancers, making it vital for cancer research. To expand p53 research, we engineered Arabidopsis thaliana to express p53 under an in...