J. Fortea

Neuropsychological profiles of dementia with lewy bodies according to alzheimer’s disease co-pathology

Alzheimer’s disease (AD) co-pathology is common in dementia with Lewy bodies (DLB) and has been linked to poorer outcomes. However, its associations with domain-specific cognitive performance across the MCI/prodromal and dementia stages, and the relationship between cognitive performance and plasma biomarkers, re...

Natural history and clinical impact of epilepsy in adults with Down syndrome: a multicentre clinical study.

BACKGROUND As individuals with Down syndrome age, they face high risks of Alzheimer's disease and epilepsy. With symptomatic Alzheimer's disease, late-onset myoclonic epilepsy in Down syndrome (LOMEDS) often emerges. We aimed to examine how epilepsy develops in Down syndrome, its timing relative to Alzheimer's disease...

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau...

Differentiating nonfluent/agrammatic and logopenic primary progressive aphasia in Catalan-Spanish bilinguals by applying multilingual multimodal machine learning to connected speech

Semantic control across Alzheimer’s disease phenotypes: cognitive mechanisms and neural correlates

Introduction Semantic cognition, our ability to understand meaning, relies on two distinct but interacting systems: one involved in knowledge representation and another in control processes. This control system is thought to comprise at least two mechanisms: controlled retrieval, which facilitates access to information...

A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease

Key Points Question Can a harmonized visual reading framework enable reliable, tracer-agnostic staging of tau positron emission tomography (PET) pathology for clinical use? Findings In this multicenter cross-sectional study of 681 participants scanned with multiple tau PET radiotracers, a 5-class harmonized visual read...

A Spanish grammaticality judgment task for neurodegenerative diseases: inflectional, transitivity, and word order comprehension in PPA and Alzheimer's Disease

Prior English-language research to Spanish is extended, demonstrating that morphosyntactic and transitivity deficits are a robust and cross-linguistically consistent feature of neurodegenerative language decline, and highlighting the importance of developing language-sensitive assessment tools for underrepresented ling...

Astrocyte reactivity identifies p-tau217-positive individuals at elevated risk of cognitive decline across the Alzheimer’s disease continuum

It is shown that elevated plasma GFAP significantly modulates the association between p-tau217 and both cross-sectional cognitive severity and longitudinal clinical decline, and support that astrocyte reactivity is associated with greater cognitive impairment and faster clinical decline among individuals with elevated...

Methodological insights and clinical outcomes in ALS and FTLD: lessons from the SPIN cohort

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration constitute a clinico‐genetic‐neuropathological continuum with marked heterogeneity and large, multimodal cohorts are needed to advance biomarker discovery and precision medicine.

Pre-dementia clinical trajectories associated with neuronal α-synuclein neuropathologic change: a retrospective cohort study

Heterogeneous pre-dementia trajectories are revealed and support is shown for combining α-synuclein detection with Alzheimer biomarkers, cognitive staging and multidomain clinical measures to improve prognosis and trial design are supported.

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.

Exome analysis of 22,319 individuals links extremely rare copy-number variants and 22q11.21 dosage to Alzheimer risk.

It is concluded that rare coding CNVs in a proportion of AD-associated genes and 22q11.21 duplication as a strong AD-risk-decreasing factor increase AD risk and Conversely, 22q11.21 duplication as a strong AD-risk-decreasing factor is identified.