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Author

J. G. Smith

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2 papers indexed here

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Open access Oct 2026

Decomposing polygenic risk of coronary artery disease into distinct biological processes

Standard polygenic risk scores capture overall genetic liability to coronary artery disease (CAD) but do not reveal the biological processes contributing to risk in an individual. Here, we applied data-driven latent factor decomposition to 526 genome-wide significant CAD-associated variants, using their associations wi...

J. Morze, K. Smith, M. Kierczak et al. · 0 citations
Open access Oct 2026

Effects of semaglutide and dapagliflozin on natriuretic peptides in type 2 diabetes: a randomized comparative study

Type 2 diabetes (T2D) is associated with a substantially increased risk of heart failure, partly mediated by myocardial stress and neurohormonal activation. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) both improve cardiovascular outcomes in T2D, bu...

C. Lejonberg, A. Rosengren, T. Czuba et al. · 0 citations

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