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Author

J. Guicheux

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Open access Oct 2026

Recapitulating the notochord to nucleus pulposus transition from human mesendoderm progenitors in 3D

Intervertebral disc (IVD) degeneration, a major cause of low back pain, is driven by the disruption of nucleus pulposus (NP) tissue homeostasis. The NP arises from embryonic notochord cells that differentiate and adapt to the hypoxic, matrix-rich environment of the developing disc. Recapitulating the developmental traj...

Julie Warin, N. Védrenne, Bluwen Guidoux-D'halluin et al. · 0 citations

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