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Author

J. H. Wildeman

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Open access Oct 2026

APOE-ε4 links CD8+ T cell infiltration to white matter inflammation in Alzheimer’s disease

APOE-ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and has been linked to immune dysregulation, yet its impact on adaptive immunity remains poorly defined. We profiled adaptive immune changes in human APOE-ε3 and APOE-ε4 knock-in (KI) mice using mass cytometry (CyTOF). To assess brain...

Sem Halters, J. H. Wildeman, H. van der Stok et al. · 0 citations

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