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Author

J. H. Yoo

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Review Open access Aug 2026

Gut microbiome: a key driver and therapeutic target of intestinal fibrosis in Crohn's disease.

Intestinal fibrosis is a debilitating complication of Crohn's disease that often leads to stricture formation, requiring surgical intervention. Despite its clinical significance, effective anti-fibrotic therapies remain an unmet need. Emerging evidence highlights the gut microbiome as a central orchestrator of fibrogen...

Jee Hyun Kim, Y. Choi, J. H. Yoo · 0 citations
Open access Aug 2026

Roflumilast Inhibits Fibrogenic Activation in Human Intestinal Myofibroblasts via Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling

Findings indicate that PDE4 inhibitors, particularly roflumilast, effectively suppress TGF-β1-induced fibrogenic activation in HIMFs by modulating MRTF/SRF and Smad-dependent pathways, highlighting the value of roflumilast for further preclinical investigation as a potential therapeutic strategy for intestinal fibrosis...

Dongju Lee, Y. Choi, In-Kyung Yoo et al. · 0 citations

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