Open access
Jul 2026
The risk of nephrotic range proteinuria and kidney failure in primary laminopathies is genotype-specific.
BACKGROUND Primary laminopathies are a heterogeneous group of rare diseases caused by nuclear lamina dysfunction due to pathogenic LMNA variants. However, despite their ubiquitous expression, LMNA variants have rarely been linked to chronic kidney disease (CKD). Here, we systematically investigate clinical implications...
Sebastian Sewerin, Charlotte Aurnhammer, Mohamed Hamed et al.
· JCI Insight · 0 citations