Author

J. Han

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Open access Oct 2026

Synthesis-aware generative design in trillion-scale chemical spaces for automated drug discovery

Autonomous drug discovery via generative molecular design is critically bottlenecked by the production of chemically intractable structures. Multi-trillion-scale make-on-demand libraries guarantee synthetic feasibility, but conventional virtual screening cannot efficiently navigate these vast spaces or address multi-pa...

Seonghwan Seo, Yulseung Sung, Sang-Yeon Hwang et al. · bioRxiv · 0 citations

Open access Aug 2026

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Trained immunity enables innate immune cells to acquire memory-like responses, offering a strategy to enhance antitumor immunity. However, the metabolic‒epigenetic mechanisms underlying this process remain poorly defined. Here, we show that lipopolysaccharide-induced macrophage training is encoded by a mitochondrial me...

Ya-Chun Yu, Yulseung Sung, S. Lim et al. · Nature Communications · 0 citations