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J. Haybaeck

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Review Open access Jul 2026

The SIRT Family: Subcellular Localization and Main Functions

The mammalian sirtuins (SIRTs), consisting of seven members (SIRT 1–7), are NAD+-dependent histone deacetylases (HDACs). Similar to other classical NAD+-independent HDACs, SIRTs regulate a wide range of key biological processes by deacetylating both histone and non-histone proteins. By linking cellular metabolism to ti...

P. Quan, Christoph Schatz, D. M. Filippini et al. · 0 citations

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