RNA interference (RNAi) is a widely conserved genome-defense mechanism that protects eukaryotes against viruses and transposable elements. We previously showed that RNAi loss can lead to hypermutation and antifungal drug resistance in the human fungal pathogen Cryptococcus neoformans, illuminating the potential clinica...
Jun Huang, Connor J. Larmore, Timothy C. Davenport et al.· bioRxiv· 0 citations
Giant viruses of the phylum Nucleocytoviricota have emerged as particularly notable due to their increasingly recognized impacts on eukaryotic genome evolution. Their origins are hypothesized to predate or coincide with the diversification of eukaryotes, and they have been detected in hosts that span the eukaryotic tre...
J. Myers, Frederik Schulz, Saleh Rahimlou et al.· PLoS Biology· 1 citation
Together, these findings establish STRIPAK as a coordinator of genome stability, morphological plasticity, stress adaptation, and virulence in C. neoformans, and demonstrate that individual STRIPAK subunits drive shared yet divergent signaling outputs that shape host-pathogen interactions.
Patricia P. Peterson, Sarah Croog, Yeseul Choi et al.· mBio· 0 citations
This study uncovers a previously unappreciated mechanism of Tps1-mediated heat adaptation in C. deneoformans, by revealing that Tps1 functions as a critical metabolic gatekeeper that safeguards glycolytic flux to sustain growth at elevated temperatures.
V. Yadav, Kahlia A. Carl, J. Heitman et al.· bioRxiv· 0 citations
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