Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity
Protein arginine methyltransferase 1 (PRMT1) activity is essential for maintaining proper eukaryotic cellular function; however, its dysregulation contributes to the progression of several human diseases and cancers, making PRMT1 an attractive therapeutic target. Efforts to inhibit PRMT1 through active-site-directed co...