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Open access Aug 2026

Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity

Protein arginine methyltransferase 1 (PRMT1) activity is essential for maintaining proper eukaryotic cellular function; however, its dysregulation contributes to the progression of several human diseases and cancers, making PRMT1 an attractive therapeutic target. Efforts to inhibit PRMT1 through active-site-directed co...

Vincent Rossi, Robert S. Wilson-Kovacs, Yuan Gao et al. · 0 citations

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