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The transcription factor CHOP helps cells switch from an emergency stress response to a chronic one, where cells survive but lose some of the functions that define their identity.
Depletion of the ESCRT proteins VPS36 or ALIX resulted in especially dramatic reductions in transfected plasmid expression, which were accompanied by reduced colocalization between the transfected DNA and CHMP4, an ESCRT protein important for endosomal membrane remodeling during intraluminal vesicle formation.
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