Author

J. Homberg

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Open access Oct 2026

Brain-wide circuit dynamics underlying stress susceptibility and resilience in male mice

Understanding the neurobiological mechanisms of stress susceptibility is key to advancing our insight into stress-related psychopathology like post-traumatic stress disorder (PTSD). Because traumatic events are unpredictable, capturing brain activity during or right after trauma is extremely difficult in humans, crea...

B. Dirven, M. Negwer, Andriana Botan et al. · Translational Psychiatry · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

Serotonin (5-HT) is critical for neurodevelopment, influencing brain maturation, emotional regulation, and social behavior. Tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme for central 5-HT synthesis, causes lifelong 5-HT depletion when disrupted. While early-life 5-HT perturbations are linked to neuropsyc...

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations