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J. Hurdle

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Review Open access Sep 2026

An integrated view of metabolic and physiological regulation of toxin production in Clostridioides difficile

ABSTRACT Clostridioides difficile is a leading cause of antibiotic-associated diarrhea, with pathogenesis driven primarily by the glucosylating toxins TcdA and TcdB. Traditionally, toxin gene expression has been explained through regulation of the pathogenicity locus by global transcriptional regulators that integrate...

Chetna Dureja, Ann M. McKelvey, J. Hurdle · 0 citations
Aug 2026

Development and validation of a novel LC-MS/MS method for simultaneous quantification of fidaxomicin and metabolite (OP-1118) from feces for gut pharmacobiome studies.

Fidaxomicin is a first-line antibiotic for treating Clostridioides difficile infection. While it has low systemic absorption and reaches high colonic concentrations, it is hydrolyzed to a less active metabolite, OP-1118. Few studies have completely described critical experimental details of liquid chromatography-tandem...

Chen-Lin Hu, Taryn A. Eubank, Ann M. McKelvey et al. · 0 citations

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