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Author

J. Javitch

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Open access Sep 2026

G protein diffusion states reveal receptor binding dynamics at single-molecule scale.

G protein-coupled receptors (GPCRs) signal through heterotrimeric G proteins, yet the kinetics of receptor-G protein interactions in cells remain poorly understood. Using single-molecule imaging, we tracked individual Gαi1 proteins diffusing in the plasma membrane, expecting that receptor binding should slow these rapi...

Signe Mathiasen, Jozsef Meszaros, Chase M. Webb et al. · 0 citations
Open access Jul 2026

Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning

It is shown that D2Rs can bypass second messenger systems to tune glutamatergic transmission through receptor-receptor interactions, providing a mechanism by which dopamine selectively gates specific glutamatergic inputs to control striatal plasticity and behavioral adaptation.

Sheng Gong, J. Adler, Ying Zhu et al. · 0 citations

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