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Open access Oct 2026

Sequence-based variant-effect predictions reveal trait-specific regulatory-layer profiles of complex-trait heritability

Partitioned-heritability studies have shown which tissues carry the heritability of complex traits, but whether the regulatory layer whose annotations are most informative for heritability within a tissue differs between traits has not been tested, because measured annotations for different layers come from different s...

B. Choi, J. Jeong · 0 citations
Open access Oct 2026

Expression predictions inform molecular interpretation of Alzheimer's disease risk loci

Sequence models predict the molecular effects of genetic variation, yet their contribution to interpreting Alzheimer's disease (AD) association signals remains uncertain. Here we analysed AlphaGenome Atlas predictions for 111,446 common variants across 75 regions from a European-ancestry genome-wide association study (...

C. B. Hyug, J. Jeong · 0 citations

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