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Author

J. Kennelly

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2 papers indexed here

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Open access Oct 2026

NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

Neuropeptidergic control of lipid metabolism is conserved and increasingly implicated in metabolic diseases, but receptor-level mechanisms remain unclear. Here, we identify the neurokinin-2 receptor (NK2R) as a central node linking tachykinin signals to intestinal lipid mobilization, epithelial composition, and mucosal...

P. A. Perez, Chung-Chih Liu, Alessandra Ferrari et al. · 0 citations
Open access Sep 2026

Design and structural basis of selective nonsteroidal inhibitors of aster cholesterol trafficking

Significance Cholesterol transport by Aster proteins from the plasma membrane (PM) to the endoplasmic reticulum is important for cholesterol homeostasis. We identify nonsteroidal Aster inhibitors with improved specificity and reduced toxicity compared to sterol-based inhibitors. YKJ-124, a low-toxicity Aster-A preferri...

Hyunsoo Kim, B. Romartínez-Alonso, Xu Xiao et al. · 0 citations

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