Open access
Jul 2026
The transcription factor IRF8 promotes the survival of differentiated effector CD8 T cells 2254435
The potential for overexpression of IRF8 during adoptive cell therapy regimens as a strategy for enhancing their long-term persistence is highlighted, position IRF8 as a cytokine-sensitive transcription factor that orchestrates the transcriptional control of apoptotic restraint, promoting sustained fitness and survival...
Uddeep Chaudhury, Alayna M. Rosales, Zoe K. Bedrosian et al.
· Journal of Immunology · 0 citations