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Author

J. Kleynhans

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Open access Oct 2026

Antimicrobial resistance trends and lineage distribution among invasive pneumococcal disease isolates pre- and post-pneumococcal conjugate vaccine introduction, South Africa.

OBJECTIVES Pneumococcal conjugate vaccines (PCV) have reduced antimicrobial-resistant invasive pneumococcal disease (IPD) globally. We evaluated trends in antimicrobial-resistant IPD and pneumococcal lineages before and after PCV13 introduction in South Africa. METHODS We analysed national, laboratory-based IPD surve...

Cebile Lekhuleni, K. Ndlangisa, L. De Gouveia et al. · 0 citations
Open access Sep 2026

Pneumococcal population structure influences the effects of air pollution on invasive disease risk in South Africa

Streptococcus pneumoniae is highly diverse, comprising over 100 serotypes and hundreds of genomic lineages amid widespread vaccination. While it can cause invasive pneumococcal disease (IPD) which exhibits pronounced seasonal spikes, the interplay between pneumococcal diversity and environmental drivers remains unexplo...

S. Belman, Cebile Lekhuleni, J. Kleynhans et al. · 1 citation

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