Oct 2026
--Paneth cell niche function is critical for intestinal stem cells in radiation injury but dispensable in GVHD.
Paneth cells (PCs) produce WNT3 and EGF in the small intestine and are thought to contribute to the intestinal stem cell (ISC) niche, which is a target of graft vs. host disease (GVHD). However, PC deletion models have failed to demonstrate substantial consequences for ISCs or other epithelial pathology. The physiologi...
Viktor Arnhold, W. Chang, M. Calafiore et al.
· Blood · 0 citations