J. Lambert

reFLASH: A proof-of-concept meta-analytic framework to validate surrogate endpoints in the absence of randomized clinical trial data.

BACKGROUND Within a meta-analytic framework, validating surrogate endpoints traditionally requires individual patient data (IPD) from multiple randomized controlled trials (RCTs). This is rarely feasible in rare and indolent diseases. We propose a proof-of-concept strategy that creates synthetic comparative evidence fr...