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Author

J. Licinio

2 papers indexed here

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Open access Oct 2026

Cross-species single-nucleus transcriptomics identifies microglial Arhgap22 as a conserved modulator of synaptic phagocytosis and depression-related behaviors

Microglia-regulated neuroinflammation is associated with major depressive disorder (MDD), yet the molecular drivers of pathological microglia-neuron interactions remain poorly defined. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) of the prefrontal cortex (PFC) in mice susceptible to chronic social def...

Rui-Min Tian, Hong-Zhou Zuo, Chen-Chen Tang et al. · 0 citations
Open access Sep 2026

851. A mechanism for PHF21B recognition of H3K36me3

Abstract Background We have recently identified the epigenetic reader PHF21B as a regulator of synaptic plasticity and social memory in mice. The PHF21B gene is located on chromosome 22q13.3, a region that is deleted in Phelan-McDermid syndrome, a neurodevelopmental disorder characterized by intellectual disability, im...

M. Wong, Q. Ma, J. Licinio · 0 citations

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