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Author

J. Lim

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Open access Sep 2026

Breast cancer-associated fibroblast-derived exosomal miR-1290 promotes triple-negative breast cancer cell proliferation

It is demonstrated that treatment with the mTOR inhibitor rapamycin and the FDA-approved rapamycin analog everolimus effectively suppressed miR-1290-induced TNBC cell proliferation, suggesting a potential therapeutic strategy for TNBC.

Jinkwon Lee, Taesang Son, Gyeonghwa Kim et al. · 0 citations
Open access Jul 2026

Pharmacological Blockade of NMUR2 Suppresses Glioma Growth by Inhibiting STAT5-Mediated Transcription of Cell Cycle-associated Genes

These findings define a previously unrecognized NMUR2/Gαq/Ca²⁺/STAT5/PIM1-FOXM1 signaling axis in glioma and support pharmacological inhibition of NMUR2 as a potential therapeutic strategy.

Yuna Roh, Taesang Son, Tae-Hee Han et al. · 0 citations
Open access Jul 2026

Alu-mediated SPAST deletion impairs golgi zinc transport and reveals a druggable vulnerability

These findings identify a primate-specific cascade linking Alu-mediated genomic rearrangements to zinc dyshomeostasis and Golgi pathology and suggest that dysregulation of the ZnT6–Golgi axis may represent a vulnerability and therapeutic target in structural variant–driven neurodegeneration and possibly in a subset of...

Youngsun Lee, Onju Ham, Hana Lee et al. · 0 citations

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