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Author

J. Lipka

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Open access Sep 2026

A scalable human neuron model of Alzheimer’s disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction

The development of scalable iPSC-neuron models enables tauopathy drug discovery and reconstructs progressive Tau seeding, fibrillization and synaptic dysfunction, and establishes a physiologically relevant, scalable platform for therapeutic screening that connects Tau seed uptake, site-specific phosphorylation, fibril...

J. Lipka, Xiwei Shan, Qiao Zhang et al. · 0 citations
Open access Sep 2026

Large-scale single-molecule analysis of tau proteoforms

Iterative Mapping of proteoforms provides insights into proteoform complexity at the single-molecule level, with implications for understanding protein regulation in neurodegenerative diseases and beyond.

James Joly, V. Budamagunta, Zheng-Jian Zhang et al. · 1 citation

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