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J. M. Mahoney

2 papers indexed here

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Open access Nov 2026

Alterations in the Immune-Fibrotic Axis Are Spatially Localized in the Aging Heart.

The immune-fibrotic axis functions as a vicious feedback loop where age-related chronic, low-grade systemic inflammation (inflammaging) drives maladaptive tissue repair and fibrosis, while senescent fibrotic cells in turn amplify systemic inflammation. In the aging heart, immune dysregulation and fibroblast activation...

Aleksandra Aljakna Khan, A. Sintou, Yue Zhao et al. · 0 citations
Review Open access Oct 2026

Target‐Engagement Prediction From Molecular Structure, In Vitro and Animal Data: A Tutorial for Early Assessment of Clinical Drug Exposure and Therapeutic/Adverse Potential Using the ANDROMEDA and PLATO Software on the InSilicoTrials Platform

ABSTRACT The target‐engagement predictor, implemented within the InSilicoTrials cloud‐based, AI‐powered platform for model‐informed drug discovery and development, enables early exploration of time‐dependent pharmacological responses. Predictions can be generated using inputs ranging from molecular structure to in vitr...

Niccolò Totis, Fianne Sips, Simona Catozzi et al. · 1 citation

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