Disrupting Biofilms by Combining Ultrasound-Stimulated Microbubbles, Anti-Biofilm Agents and Antibiotics.
OBJECTIVE Chronic infections are often sustained by biofilms, which exhibit high tolerance to antimicrobials and immune clearance. Ultrasound (US)-stimulated microbubbles (MBs) have shown promise for biofilm disruption, yet their integration with chemical anti-biofilm agents and antibiotics has not been systematically...