MRP4 deficiency exacerbates diet-induced MASLD through dysregulation of hepatic lipid handling.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is characterized by impaired hepatic lipid homeostasis. Multidrug resistance-associated protein 4 (MRP4/ABCC4) is a sinusoidal efflux transporter of endogenous signaling metabolites. We previously showed that Mrp4 knockout (Mrp4-/-) mice develop prolonged...