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Author

J. Millman

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Open access Sep 2026

Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background

Summary Genome-wide association studies have identified IFIH1, which encodes the double-stranded RNA sensor MDA5, as a type 1 diabetes (T1D) risk locus. The IFIH1 E627∗ variant is associated with protection from T1D, whereas A946T is associated with increased risk. To examine how these variants influence islet response...

Daniel A. Veronese-Paniagua, Cameron Banks, Kameron Bradley et al. · 0 citations
Open access Jul 2026

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

While allogeneic grafts undergo strong immune infiltration and tissue remodeling, autologous stem cell-derived islet grafts remain largely protected, even in the presence of autoreactive T cells, indicating that additional stimuli may be required to trigger autoimmune β-cell targeting in vivo.

Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al. · 0 citations
Review Open access Jul 2026

Applications of Stem Cell–Derived Islets and Emerging Experimental Platforms to Understand Diabetes

Recent clinical reports in the use of SC-islets to restore islet function and their versatility as a platform for disease modeling and drug screening are highlighted while emphasizing current strategies aimed at overcoming their limitations and enhancing their therapeutic potential.

Noyonika Mukherjee, J. Millman · 0 citations

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