Author

J. Mintseris

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Open access Oct 2026

Ribosome remodeling drives translation adaptation during viral infection and cellular stress.

The ribosome is the highly conserved molecular machine that decodes mRNAs during protein synthesis. Here, we discover that, while traditionally thought to consist of a uniform set of proteins, ribosome composition is reprogrammed to adapt to intrinsic and external cellular perturbations. During infection of human cells...

Hsin-Yu Tsai, Luo-Chen Liu, R. H. Fleming et al. · Molecules and Cells · 1 citation

Jul 2026

An AI-enabled structural atlas decodes kinase specificity across the human proteome.

KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.

David Vanderwall, Edward L. Huttlin, J. Mintseris et al. · Nature Biotechnology · 0 citations