Fused in sarcoma (FUS) is an RNA-binding protein that undergoes phase separation with RNA and other cellular components, forming ribonucleoprotein (RNP) granules. While recent advances in the study of biomolecular phase separation have focused on protein-protein interactions, information on the molecular details of pro...
Tong-Yin Zheng, Kandarp A. Sojitra, Samara Cummings et al.· Angewandte Chemie· 0 citations
Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...
Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al.· Journal of Chemical Physics· 0 citations
It is found that affinity governs the phase boundary, resistance to chemical perturbation, and molecular mobility of condensates in vitro and in human cells and is shown to be a quantitative determinant of condensate phase behavior, internal dynamics and biochemical output.
Andres Reyna, Madyson O. Briggs, Alexander F. Russell et al.· bioRxiv· 0 citations
Neurons can maintain proteostasis by extruding protein aggregates and damaged organelles via large extracellular vesicles called exophers. However, the biophysical rules governing exopher cargo selection remain poorly understood. Here, we discovered that biomolecular condensates can localize to exophers and investigate...
Mayur Barai, E. Chuang, Shuo-Lin Weng et al.· bioRxiv· 0 citations
Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...
Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al.· bioRxiv· 0 citations
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