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Open access Oct 2026

Decomposing polygenic risk of coronary artery disease into distinct biological processes

Standard polygenic risk scores capture overall genetic liability to coronary artery disease (CAD) but do not reveal the biological processes contributing to risk in an individual. Here, we applied data-driven latent factor decomposition to 526 genome-wide significant CAD-associated variants, using their associations wi...

J. Morze, K. Smith, M. Kierczak et al. · 0 citations
Open access Oct 2026

Proteomic signatures reveal why not all apolipoprotein B-containing lipoproteins are equal in atherosclerosis

All apolipoprotein B (apoB)-containing lipoproteins are causal risk factors for coronary artery disease (CAD). However, triglyceride-rich lipoproteins (TRL) and lipoprotein(a) [Lp(a)] exhibit greater per-particle atherogenicity than low-density lipoprotein (LDL) through mechanisms that remain incompletely underst...

J. Morze, E. Bjornson, Michael Y. Mi et al. · 0 citations

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