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Open access Aug 2026

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking

Adolescent stress is a lifelong risk factor for addiction, but the underlying neural circuit changes remain unknown. Here, we show that chronic unpredictable stress in adolescent mice causes a prominent increase in punishment-resistant reward-seeking – behavior tightly linked to the diagnostic criteria for addiction –...

J. Nadel, Evan S. Swanson, Manhua Zhu et al. · 0 citations

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