Open access
Sep 2026
ZBTB10 inhibits ccRCC progression by epigenetically silencing GPX4 through a self-regulatory ZBTB10/DNMT1/FBXW4 loop
ZBTB10 is identified as a suppressor of ccRCC progression that transcriptionally represses GPX4, a central inhibitor of ferroptosis and an epigenetic mechanism linking ZBTB10 to ferroptosis in ccRCC is revealed and targeting the ZBTB10/DNMT1/FBXW4/GPX4 axis may provide a therapeutic strategy for limiting ccRCC progress...
Wei Song, Hou-Liang Zhang, Yi-Di Wang et al.
· Cell Death & Disease · 0 citations