Author

J. Nogales

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Open access Sep 2026

ML4SD: Leveraging Machine Learning and High-Throughput Search Algorithms for an Iterative Growth-Coupled Design Innovation

Optimizing microbial biomanufacturing is required if renewable and waste carbon are to replace petrochemical routes at competitive titers, rates, and yields. Growth-coupled (GC) production supports that goal by linking target synthesis to biomass formation, so product formation is required for growth. Constructing knoc...

Alvaro Garantilla Becerra, J. Nogales · bioRxiv · 0 citations

Open access Jul 2026

Functional redundancy driven by isocitrate dehydrogenase enhances metabolic robustness in Pseudomonas putida KT2440.

Findings support a model in which specialized isoenzymes with conditional redundancy, rather than simple redundancy, in P. putida enables the cell to balance energy production with biosynthetic demands, which might facilitate metabolic adaptation under fluctuating environmental conditions.

Maria-Tsampika Manoli, Sandra Herrera Alarcon, Álvaro Gargantilla-Becerra et al. · Microbial Cell Factories · 0 citations