Author

J. P. Leone

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Open access Oct 2026

Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses

Abstract Purpose: Human epidermal growth factor receptor 2 (HER2)–positive breast cancer brain metastases (BCBM) frequently harbor PI3K/AKT/mTOR alterations. Preclinical HER2+ BCBM models demonstrated durable tumor regression with dual PI3K and mTOR inhibition. Our phase II trial evaluated paxalisib, a brain-penetrant...

E. Seguí, Jorge Gómez Tejeda Zañudo, N. Graham et al. · Cancer Research Communicatio... · 0 citations

Oct 2026

21-Gene recurrence score assay in pN2-3 Early-Stage breast cancer: a national cancer database study.

BACKGROUND The clinical utility of the 21-gene recurrence score (RS) for guiding adjuvant chemotherapy in patients with pN2-3 early-stage breast cancer (eBC) has not been evaluated in prospective trials. This study aims to assess adjuvant chemotherapy benefit in patients with pN2-3 eBC who underwent RS testing and had...

C. Valenza, Yue Zheng, J. P. Leone et al. · Journal of the National Canc... · 0 citations