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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

J. P. Pezacki

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Open access Aug 2026

SARS-CoV-2 Orf3a protein interaction mapping using unnatural amino acid incorporation

It is demonstrated that genetically encoded, site-specific photo-crosslinking enables selective capture of transient interactions that are often missed by nonspecific 254 nm UV crosslinking approaches and highlights Orf3a as a multifunctional protein that engages diverse host pathways.

Eryn Lundrigan, Noreen Ahmed, J. P. Pezacki · 0 citations
Open access Aug 2026

Towards programmable metallonucleases via genetic code expansion

The potential of BpyAla-mediated nucleic acid cleavage is discussed, with emphasis on the development of next-generation BpyAla analogues, the exploration of alternative metal cofactors, cooperative and multi-residue design strategies, and the expansion of compatible protein scaffolds and nucleic acid substrates.

Eryn Lundrigan, Matthew T. O'Neill, J. P. Pezacki · 0 citations

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