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J. Pérez-Simón

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Oct 2026

Genomic and clinical landscape of RAS mutations in acute myeloid leukemia.

RAS mutations are recurrent in acute myeloid leukemia (AML); yet, their genomic and clinical landscape remain poorly characterized. We analyzed centralized molecular profiling data in 8,553 patients with newly diagnosed AML. Of these, 1,775 (21%) harbored RAS mutations: NRAS in 1,103 (13%), KRAS in 445 (5%), and both i...

E. Rodríguez-Arbolí, E. Soria-Saldise, E. Barragán et al. · 0 citations
Open access Sep 2026

Immunotherapy refractoriness and early post-alloHCT relapse define ultra-high-risk B-ALL after CD19 CAR T-cell therapy.

CD19-directed CAR T-cell therapy (CART19) has transformed relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) management, but the prognostic impact of immunotherapy sensitivity and post-allogeneic hematopoietic cell transplantation (alloHCT) relapse timing in real-world practice remains unclear. We re...

V. Ortíz-Maldonado, J. Galimard, Giorgio Ottaviano et al. · 0 citations
Open access Sep 2026

Integrated analysis of hematopoietic changes following heterochronic bone marrow transplantation between young and aged mice.

BACKGROUND aging is a multifactorial process characterized by progressive loss of tissue homeostasis and regenerative capacity, with haematopoiesis being profoundly affected. Age-associated changes in hematopoietic stem cells (HSCs) include increased frequency but reduced function, impaired self-renewal, and myeloid bi...

J. A. Bejarano-García, Melanie Nufer, Rocío Caracuel et al. · 0 citations
Open access Aug 2026

Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.

Pegtarazimod reduced aGVHD in mice by suppressing pro inflammatory neutrophil effector functions and preserving enterocyte integrity and the clinical trial data support tolerability of pegtarazimod in aGVHD patients and further studies are needed to determine efficacy.

Verena Holzmüller, Jana Gawron, Ann-Cathrin Burk et al. · 0 citations
Open access Jul 2026

Bridging preclinical development and clinical manufacturing: a translational GMP-Platform for lentiviral vector production in academic CAR T-Cell therapy

An integrated GMP facility is established and validated for aseptic LV production within a public healthcare setting, establishing a GMP-compliant academic platform for scalable LV manufacturing, enabling decentralized, cost-effective, and clinically compliant supply.

Maribel Lara-Chica, Blanca Arribas-Arribas, Raquel Muñoz-García et al. · 0 citations

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