J. Peter

MeCP2 MBD-ID module: a unified DNA/RNA binding interface disrupted in Rett syndrome

Abstract Rett syndrome neurodevelopmental disorder is caused by mutations in the epigenetic regulator MeCP2. While the MeCP2 methyl-CpG binding domain (MBD) is well-characterized, the function of the adjacent intervening domain (ID) remains largely understudied. The ID has been described as a distinct RNA-binding regio...