Open access
Aug 2026
Genetic clusters of BMI reveal symptom-specific causal effects on depression.
It is indicated that the causal effect of BMI on depression detected in typical non-clustered Mendelian randomization is driven to an extent by appetite, with no or inconsistent evidence for effects on core psychological symptoms such as anhedonia and depressed mood.
Stephanie Sheir, Giulia G. Piazza, N. Davies et al.
· Molecular Psychiatry · 0 citations