Open access
Sep 2026
Whole‐Genome Analysis of HEV Under Sequential Ribavirin Pressure Reveals Early Minor Variants Predicting Resistance
Ribavirin (RBV) failures in chronic hepatitis E virus (HEV) infection may arise from genomic adaptation, yet the contribution of minor variants remains insufficiently explored. Using a shotgun metagenomics based on next‐generation sequencing to obtain the full HEV genome, we analyzed longitudinal HEV populations from s...
Sergi Colomer-Castell, Marta Ibáñez-Lligoña, C. Campos et al.
· Journal of Medical Virology · 0 citations