Author

J. R. Highley

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Open access Oct 2026

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer’s disease

Neurotoxic intermediates formed during amyloid-β(Aβ) aggregation are thought to drive Alzheimer’s disease, yet their rarity and transient nature have obscured their identity and formation pathways in the human brain. Here, we combine super-resolution microscopy and single-molecule functional imaging with kinetic modell...

Agnieszka Urbanek, A. Dear, David P. Rhodes et al. · bioRxiv · 0 citations

Open access Sep 2026

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death generally 3–5 years post-symptom onset. ALS is a cell- and non-cell-autonomous disease, with glia such as astrocytes influencing disease pathology and progression. Our laboratory...

Benjamin J. Hall, Yasmina M. Ebrahim, Joanne L. Sharpe et al. · International Journal of Mol... · 0 citations