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Author

J. R. Tejedor

2 papers indexed here

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Open access Sep 2026

Patient-Derived Fibroblasts as a Clinically Relevant Model of Kearns-Sayre Syndrome.

OBJECTIVE Kearns-Sayre syndrome (KSS) is characterized by single large-scale mitochondrial DNA deletions and by severe early-onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking. We aimed to determine whether patient-d...

L. Valls-Roca, A. Vilaseca-Capel, Judith Cantó-Santos et al. · 0 citations
Open access Aug 2026

Replicative history as a major determinant of epigenetic noise across human tissues

Cumulative mitotic history showed a stronger association with epigenetic noise than chronological age, explaining most of its variance particularly within CpG-rich regulatory regions, while genomic context modulates regional vulnerability to methylation information loss during aging.

A. Peñarroya, J. J. Alba-Linares, R. F. Pérez et al. · 0 citations

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