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Sep 2026

Pharmacological modulation of GLI signaling promotes human iPSC-derived cardiomyocyte maturation via PGC1α-associated mitochondrial programs.

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a scalable platform for cardiovascular research but remain structurally and functionally immature, limiting their utility for studying cardiac biology, disease mechanisms, and clinical translation. Developmental signaling pathways that coord...

M. Shameem, Ahmed Sharara, Ina Xhelilaj et al. · 0 citations
Review Open access Aug 2026

An Immunological and Translational Framework for Interspecies Exogenic Liver Transplantation

This work examines exogenic liver transplantation through an immunology-first, clinical framework with emphasis on early graft injury driven predominantly by innate immune mechanisms at the vascular interface, including complement activation, macrophage mediated clearance, thrombocytopenia, and coagulation dysregulatio...

J. Rao, Anala V. Shetty, Sabarinathan Ramachandran et al. · 0 citations

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