J. Rey

Stoichiometric Binding of Cyclophilin-A to The HIV-1 Capsid Modulates Its Mechanoelastic Properties.

Protein nanocapsules balance structural rigidity with mechanical deformability to perform their biological functions. The HIV-1 capsid, a ∼ 120 nm conical shell assembled from over 1000 capsid protein (CA) subunits, exemplifies this challenge: it must be stable to protect the viral cargo while remaining sufficiently de...