Highly polymorphic classical major histocompatibility complex class I (MHC-Ia) molecules present peptides to T cell receptors (TCRs) expressed on CD8+ T cells. In contrast, non-classical MHC-Ib molecules are less polymorphic, and the structural principles governing their recognition by TCRs remains poorly understood. H...
Luke Tennant, C. Jobichen, Mai T. Tran et al.· Journal of Biological Chemis...· 0 citations
Mucosal-associated invariant T cells (MAIT cells) are innate-like immune cells (T lymphocytes) that protect against bacterial infections. They are potently activated by the microbial metabolite 5-(2-oxopropylideneamino)-d-ribitylaminouracil (5-OP-RU), which bonds covalently to an amine of a specific lysine residue of t...
Jeffrey Y. W. Mak, H. N. Hoang, W. Awad et al.· Chemistry· 0 citations
BfaGCs were demonstrated to function as immunomodulatory mediators influencing the host’s defence in the context of NKT cells, affirming BfaGCs as bona fide CD1d ligands that modulate host immune defences via NKT cells.
P. Thirunavukkarasu, Vasudha Maddali, Da-Jung Jung et al.· Journal of Immunology· 0 citations
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