How Lewy pathology forms and diversifies remains a central question in Parkinson's disease research. A recent study by Mahul-Mellier and Colleagues proposes a dynamic model in which inclusion maturation and organelle remodeling drive pathological heterogeneity, reshaping concepts of disease mechanisms and providing new...
E. Frattini, J. Schwamborn· TIPS - Trends in Pharmacolog...· 0 citations
Interpreting large-scale single-cell transcriptomic data remains a major challenge for understanding disease mechanisms. Recent single-cell foundation models learn rich representations of gene relationships across millions of cells, yet methods for translating these embeddings into biologically interpretable gene netwo...
Jun Yin, Maya L. Gosztyla, Birkan Gokbag et al.· bioRxiv· 0 citations
This review summarizes drug screening studies in midbrain organoids across genetic, toxin-based, and α-synuclein preformed fibril models and critically assess current limitations and outline how artificial intelligence integration and assembloid platforms are advancing organoid-based drug discovery towards regulatory a...
Alise Zagare, J. Jarazo, J. Schwamborn· Drug Discovery Today· 1 citation
Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.
Lisa M. Smits, S. Magni, K. Grzyb et al.· npj Parkinson's Disease· 0 citations
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