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J. Schwamborn

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Sep 2026

Dissecting the Lewy body.

How Lewy pathology forms and diversifies remains a central question in Parkinson's disease research. A recent study by Mahul-Mellier and Colleagues proposes a dynamic model in which inclusion maturation and organelle remodeling drive pathological heterogeneity, reshaping concepts of disease mechanisms and providing new...

E. Frattini, J. Schwamborn · 0 citations
Open access Jul 2026

Interpretable gene networks from single-cell foundation models reveal conserved neurogenic dysfunction in Parkinson’s disease

Interpreting large-scale single-cell transcriptomic data remains a major challenge for understanding disease mechanisms. Recent single-cell foundation models learn rich representations of gene relationships across millions of cells, yet methods for translating these embeddings into biologically interpretable gene netwo...

Jun Yin, Maya L. Gosztyla, Birkan Gokbag et al. · 0 citations
Review Open access Jul 2026

Brain organoids in Parkinson's disease drug development: Human-specific models for translational discovery.

This review summarizes drug screening studies in midbrain organoids across genetic, toxin-based, and α-synuclein preformed fibril models and critically assess current limitations and outline how artificial intelligence integration and assembloid platforms are advancing organoid-based drug discovery towards regulatory a...

Alise Zagare, J. Jarazo, J. Schwamborn · 1 citation

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