Proliferative vitreoretinopathy: An integrative, multi-pathway perspective on pathogenesis and therapy.
Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment-restricted mechanisms do not fully explain the heterogeneity, biomechanical behavi...