Open access
Sep 2026
A water-pinning hotspot drives templated tau aggregation
Tau assembles into fibrillar aggregates that are pathological hallmarks of a group of neurodegenerative diseases collectively called tauopathies. Templated aggregation of naïve tau to seeding-competent fibrils that proceed from cell to cell is a key driver of prion-like progression of tauopathies. This study tests the...
Chung-Ta Han, Karen Tsay, Samuel Lobo et al.
· bioRxiv · 0 citations