Granzyme B (GzmB) is a serine protease traditionally recognized for its role in lymphocyte-mediated apoptosis. In specific conditions, GzmB accumulates in the extracellular milieu and retains its proteolytic activity, cleaving extracellular proteins thereby contributing to disease progression. Nevertheless, pathologica...
A. Aubert, A. Prudova, Jeffrey S. Tang et al.· Matrix Biology· 0 citations
Netrin-1 is a secreted laminin-like protein that functions as a guidance cue for axon pathfinding in development. Netrin-1 also modulates synapse formation in developing neurons and long-term potentiation in mature neurons. Netrin-1 is expressed in human neurons; however, its intracellular distribution and trafficking...
T. Y. Leung, J. Sidhu, A. Hsieh et al.· Cytoskeleton· 0 citations
Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these serine proteases also play roles in non-cytotoxic...
Daniele P. Ferrari, J. Sidhu, Karen Jung et al.· Cellular and molecular neuro...· 0 citations
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